This category is for characters who are scientists.
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- Leo Scarlett
- Sam Scarlett
- Science Ghoul
- Science kid (The Case of the Hi-Fi E.T.s)
- Scientist (The Crown Jewel of Boxing!)
- Scientist Scooby
- Albert Shaggleford
- Dr. Sharkey
- Simon Simonson
- Sivana Family
- Sivana Junior
- Doctor Sivana
- Georgia Sivana
- Dr. Slavinski
- Amanda Smythe
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- Melanie Staples
- Ned Staples
- Eric Staufer
- Steve (Scooby-Doo and the Alien Invaders)
- Norman Sumpump
- Professor Svankmajer
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