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The Colosseum is a famous tourist attraction in Rome. Gladiatorial combats were held there in the days of the Roman emperors.
It is not to be confused with the smaller Pompeii Colosseum.
The Richie Rich/Scooby-Doo Show
Shaggy Rogers, Scooby-Doo, and Scrappy-Doo traveled back in time (possibly the result of a strange pizza they ate) and confronted the gladiator Rocky Maximus there. (Et Tu, Scoob?)
Scooby-Doo and the Cyber Chase
The gang also once went to a replica of the place in cyberspace.