- This article is for additional biographical facts about Daphne that can be gathered from select video games.
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Daphne Blake is the rich and fashionable member of Mystery Inc.
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- Uncle Blake: Daphne's uncle and also a hotel owner of Blake's Hotel. (Scooby-Doo Mystery (Sega Genesis))
- Aunt Mabel: Daphne's aunt, who works at Bradshaw Manor. (Scooby-Doo Mystery (Snes))
- Grey DeLisle who played this Daphne in the THQ games has also played her original incarnation since the direct-to-video animated film, Scooby-Doo and the Cyber Chase.