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- Mutated humans (only appearance; dies)(miscellaneous speaking)
- Mutated human with fangs (dies; regenerates)
- Vlad the Impaler (only appearance; dies)
- Smart dogs (single appearance)(no lines)
- Scrappy-Doo (cameo)
- Four scientists (mentioned)
- Huck (only time mentioned)
- Dr. Krebs (mentioned)
- Velma's googles
- Scooby's emotigoogles
- Velma's drone
The following credits try to match how they are displayed in the comic as much as possible:
- Monsters, Mayhem and Apocalyptic Antics Courtesy Of:
- Keith Giffen, J.M. DeMatteis, Howard Porter, & Dale Eaglesham
- Hi-Fi - colors
- Nick Napolitano - letterer
- Jim Lee with Alex Sinclair - main cover
- Denys Cowan, Klaus Janson & Steve Buccellato - variant cover
- Brittany Holzherr - asst. editor
- Marie Javins - editor
- Based on a Concept By: Jim Lee
- Daphne takes on a more decisive role, and begins to stop blaming Velma, as Velma starts to take the blame for what happened.
- The Mystery Machine's license plate number reads "195-343" in reference to the direct-to-video film, Scooby-Doo! Abracadabra-Doo, and the few other ones to follow.
- Fred tries to keep them together, forshadowing his leadership skills.
- Shaggy takes Fred's line, "We're all in this together" as a reference to the film, High School Musical.
- A missing smart dog is called "Huck" and has a southern drawl, a reference to Huckleberry Hound.
- Mall-Mart is a parody of Wall-Mart.
- None known
Inconsistencies/continuity errors and/or goofs/oddities
- Daphne reminds Velma that Fred said the superstore had a lot of electronics, when it was actually Shaggy who said that.