Great Skull Island is the site of a hotel.
The Scooby-Doo Show
The gang go to visit Daphne's friend, Lisa, for her birthday, which is at a very old hotel on Great Skull Island that Lisa would inherit on the day after her eighteenth birthday. Velma says that it is believed that there are vampires on the island, but she herself thinks it is nonsense. But when a real vampire shows up and Lisa is turned into a vampire herself, the vampire legend becomes very believable.