La Serena is a small, popular spa and resort town in the desert. It was certified by the U.S. Bureau of Supernatural Forces to be the "least haunted town in America." Of course that didn't stop it from having trouble with Phantosaurs while the gang was there.
Scooby-Doo! Legend of the Phantosaur
As Shaggy was told by doctor not to get in the Mystery Machine, Fred Jones painted painted the some of the words over making it the "Mustard" Machine. Along the way, they went to different spots, including a tattoo parlor for Shaggy. Fred then turned on the G.P.S. to get to La Serena.