Medusa is a Gorgon who can turn people to stone.
- Medusa: Can be seen dancing with Wolfman, Dracula, Igor, Frankenstein, and Gill-Man in the opening theme song of The New Scooby-Doo Mysteries.
- Mask of Medusa: A mask that can petrify people, appearing in the The New Scooby-Doo Mysteries episode, The Stoney Glare Stare.
- Medusa: Daphne dressed herself as a Gorgon to stop the Centaur, in the What's New, Scooby-Doo? episode, It's All Greek to Scooby.
- Velma once gave a lecture on the history of Medusa, in the Scooby-Doo comic story, Velma's Monsters of the World: Medusa, published by DC Comics.