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Milissa lived from 1733-1788; she was tragically killed by the town of Salem because they believed her to be a witch.
The Scooby-Doo Show
Hundreds of years later, Arlene's twin had set her up by making it appear that Milissa had returned as the Ghost Witch of Old Salem through Arlene, since she apparently looked like Milissa, knowing this would send the townsfolk on a witchhunt, driving Arlene out of town and leaving her the family inheritance.