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* Physical appearance.
* History is incomplete.
Mrs. Hudson was the disguise of Dorian Wormwood, the retired stage actor, pretending to be his own cook.
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She seemed to have a strong dislike for Ronald Adair, and accused him of the murder of Wormwood.
Scooby-Doo, Where Are You? (DC Comics)
The fact that the name "Mrs. Hudson" was the same as the landlady of Sherlock Holmes was no coincidence. All the names were picked for associations with Holmes, as clues.