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The big head form of Dr. Phineus Phibes resulted when he took an experimental nano-tech formula in roll-on form.
He had a huge head, which made him top-heavy so that he had difficulty moving around.
He enjoyed the side effects of speed reading and instant comprehension in spite of the side effects, and invented a stupidity gas that would make everyone else in the world into an idiot so he could be even more mentally superior.
Shaggy & Scooby-Doo Get A Clue!
Insert details here. (Don't Get A Big Head
- This may be a parody of the Marvel Comics villain called "The Leader", with the huge head side-effects played for laughs.