After eating a cursed pizza, Shaggy starts to grow into a Godzilla-like monster whenever he goes to sleep, and he starts eating everything in sight. Now the gang are running around Tokyo trying to get away from the police who want to capture Shaggy.
While in Egypt on an archeological dig with Melbourne O'Reilly, the gang encounters Pharaoh Scamses the 15th - a mummy who has a knack of turning tourists into zombie minions. Even worse for the gang is the fact that they are in danger of being turned into zombies themselves.
The gang travels to an old Transylvanian castle on a rainy night to watch the shoot of the Hex Girls' new music video Wanna Wed, But I Fled. But when they get there, they find out that the band is breaking up, since there's a vampire on the loose. Fred decides to go straight to trapping the vampire. They do so, only to discover there's another vampire lurking around. It's up to Scooby and the gang to solve the mystery and prevent the Hex Girls from breaking up.
After the gang votes on their destination they end up at the annual dog show courtesy of Scooby. There Shaggy runs into an old acquaintance Meadow and her dog, M'Lady Moonbeam. However, the gang then has an unpleasant run-in with a cat creature who seems bent on ruining the dog-show and stealing the puppies of former winner dog, Crissie.
After Shaggy wins a trip to the Scooby Snacks Factory The gang prepares for a well deserved holiday. Unfortunately there is very high security in the factory due to spies and worst of all the ghost of a former employee who died in the Scooby Snacks paste vat is lurking in the shadows.