During a riot at the Crystal Cove High School soccer game, the hideous goddess of love appears to entrance all the students into her spell. Throwing strange flowers around each person, they slowly start to fall in love with everything in town, eventually losing their minds. The next day, the gang stand inside the hallway aware of the odd attractions between students that would have never occurred before. Once admitting that he never studied for the test, Shaggy realizes that there's a substitute teacher relieving him from the test. Shaggy went to greet the substitute only to realize that Aphrodite is posing as one. Her ugly appearance distracts Shaggy long enough for her to blow a handfull of her mysterious flowers into his face, filling him with the love that the town was filled in.
The day falls through with the Mystery Inc. being infected with the love regaining their relationships with each other. Later we find Scooby roaming the halls in search for his owner only to find the startling Aphrodite that attempts to bring him into the love with the rest of the town. Once realizing that Scooby is immune to her spell, she demands that the adoring people capture him. Scobby, of course, runs away from the school and into the town who's eerie love begins to grow intensely. Aphrodite abuses her power, controlling the gang to run down Scooby-Doo into the road, but he narrowly escapes into an ally where he finds Pericles, escaped from prison. Scooby hardly believes Pericles when he claims he's willing to help saving the town despite his recent imprisonment and inlists Scooby's help for the ingredients to the antidote.
Pericles guides Scooby through many locations retrieving the ingredients from churches, museums, and mines in search for pewter found commonly in stained glass windows, the ectoplasm of a spirit, and Rose Quartz. After finding each successfully, they return to the school to combine them, creating a green liquid. Thinking they're safe, they're proven wrong when Aphrodite pounds down the door with her minions under her spell that have been demanded to steal the antidote before they save the town. The two are finally escaped and revive the gang back into their normal state, angering the people in the love. Angel Dynomite, who states she has no sense of smell, drives the mystery machine to their rescue from the attacking town.
The gang try to settle what really happened while they were under her love spell, and what it meant to them while shuffling through the library. Though Fred and Daphne both agree that they didn't need the spell, Velma and Shaggy are both reluctant to show their true feelings. Thinking about the attire that Aphrodite had dressed in, the gang realize she's chosen a prom dress and traced it down to a girl who was laughed out of the school by a vicious joke during prom, who's name is Amanda Smythe. The gang, with Pericles and Angel's help, then recreate the antidote into many canisters that they had disguised themselves. Dressed as the common love strucked citizens, the gang crash the prom that the citizens have created to honor the new queen of Crystal Cove, Aphrodite.
"Quiet now, sweet pup. All you need is the love.(blows her love spell on Scooby, but nothing happens) Sorry ugly lady, not feeling it. It's not working. Get him!"
— Scooby and Aphrodite '
Pericles: "Are you ready, innocent canine comrade?"
Pericles: "Then let's save ourself a town. The antidote to stop Aphrodite has several distinct components. Pewter: found in grout used only in stained-glass windows of the 18th century. Ectoplasm: or as it's more commonly known, ghost mucus. And finally, rose quartz, mined in the caves beneath Crystal Cove. The antidote is complete. Now load the final cylinder. We don't have much time. Let's pack these up quickly."
Aphrodite: Fools! You think you can stop me?!
Aphrodite: "I will have my crown!"
Scooby and Pericles: "Crown?"
Aphrodite: "Get them! Seize the antidote!"
— Scooby, Pericles and Aphrodite '
"Are tears of joy inappropriate? Not at all, tears are just the beginning."
— Aphrodite and Ethan after being charmed '
"They shall be made sacrifice to the goddess of love, which is to say...me!"
— Aphrodite '
"I am the goddess of love. Bow at the feet of Aphrodite! I think you mean Amanda, Amanda Smythe"
— Velma unmasks Aphrodite '